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As my wife noted, ENDOcannabinoids, not EXOcannabinoids.
- The mechanism for how mutations in NL3 lead to endocannabinoid signaling deficits remains unclear. Could lacking properly functioning NL3 be interfering with endocannabinoid secretory machinery? Could it be somehow causing degradation of endocannabinoid signaling ligands? “We’re left without a really good idea of what it’s doing in single synapses or whether it’s effective behaviorally,” Alger said. Moreover, it is not yet clear how endocannabinoid signaling deficits would be involved in autistic symptoms, the authors said.
- Alger added that, if the endocannabinoid system does turn out to be connected to autism in humans, medical marijuana could turn out to hold possibility for treating autism. But Südhof said that he did not know at this point whether marijuana would intensify or ameliorate autistic symptoms.