My apparent and almost total inability to draw satisfaction from accomplishing goals. I've done some pretty awesome stuff, and continue to do awesome stuff and the exact minute I'm done, all good feeling, all gratification, all the life-affirming and will-to-live sustaining positivity gets washed away and I'm back to "Here are the fundamental problems in your existence. None of what you just did has improved upon those fundamental problems in any material way, shape or form. Why are you fucking around instead of trying to fix those problems?" I suspect that were I able to, in the long term, feel good about the things I've done/am doing, several other problems would resolve as a matter of course. Hard to have stress-induced gouty arthritis when you're not constantly in fight or flight, gotta-save-the-whole-world-plus-myself panic.