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comment by thundara
thundara  ·  3537 days ago  ·  link  ·    ·  parent  ·  post: Don't edit the human germ line

I don't yet have a stance on the birth of kids with genetic differences. It's a complex topic that I agree will be a growing issue in future decades (unless new technology comes along, as with induced stem cells just after the stem cell ban was lift).

    I think it's going to happen. Someone is going to be willing to push the envelope and it will make them a billionaire or kill them.

A few of the early gene therapies hit the wrong targets and turned on oncogenes, given most of the patients cancer. Safety and translation to the clinic (and also intellectual property) are both top priorities in the relevant research right now, and there's plenty continuing research on making CRISPR / TALENs / ZFNs (the top 3 gene-editing enzymes) more specific and predictable.

There's some line where safety concerns outweighing the benefits transitions to the latter outweighing the former. But it's grey and I don't think the research is quite there. It's definitely not far off though.





OftenBen  ·  3535 days ago  ·  link  ·  

    I don't yet have a stance on the birth of kids with genetic differences.

Poor dodge, I expected better from you. ;]

I specifically said disease. I specifically didn't say differences, and for this exact reason. I'm not talking about bullshit like 'Neurodivergence Acceptance.' I want to know if you think it's okay for people to choose to have babies with Tay-Sachs or Harlequin-type Ichthyosis?

thundara  ·  3535 days ago  ·  link  ·  

Would I encourage my partner to abort in those cases? Probably. Am I comfortable telling others to abort their kids? No. Making that law? I'd be crucified for it.

It's specifically a dodge because there's a discrepancy between what I would choose and what I think society as a whole should choose.

OftenBen  ·  3535 days ago  ·  link  ·  

My bioethics professor always encouraged us to use a particular thought experiment when we were facing an ethical problem. He said to ask the question universally, usually phrased as 'What would society look like if everyone made the same choice?' Now, for that question to have any meaning in the context of our discussion we would have to go disease by disease to ascertain the 'rightness' or 'wrongness' of preventing pregnancies in given situations. For most of the ones I listed however, I think that those embryos should never, in any case or situation be implanted and/or carried to term. (I'm separating conception and pregnancy here, assuming technical limitations requiring/allowing these decisions to be made.)

thundara  ·  3535 days ago  ·  link  ·  

I still don't think you can say that everyone with every one of those diseases would be better off not being born for them. Some are treatable, some may one day be curable. Cystic fibrosis used to be a death sentence, but recent drugs can completely fix certain mutations.

Still, in the constrained case of uncurable, developmental defects that lead to a short lifetime of pain, followed by death, I would agree. But that's a bit more limited than what you're saying.

Appreciate the discussion.

OftenBen  ·  3535 days ago  ·  link  ·  

Every single one? Of course not.

But I am concerned most with primary prevention, Stop new cases from occurring. We have the technology to prevent all sorts of terrible diseases. We are, in a lot of cases, choosing not to use them.

Likewise.