There aren't, really, which is kind of a shame. Games focused on religion would be a really interesting idea to explore. In Binding of Isaac the titular character is about to be sacrificed by his mom, who watches too many Christian Info-TV Shows and thinks she hears a voice from God. It's...really, really weird, you unlock characters like Cain and Azazel and kill things using your tears. You're not into videogames I'm sure, lil, but you should check out Indie Game: The Movie, which is a documentary about a bunch of independent game developers, one of whom makes Binding of Isaac. I'd like to hear what you think of it.
i totally just saw this. I'm loving rebirth right now, especially because vanilla Issac just ran like shit on my macbook. You are obviously better at video games than I am (just recently beat mom's heart, but before then I was at a -37 winning streak).
I actually ended up switching to controller because using WASD/^<v> was inflaming one of the muscles in my hand really badly. Inflamed hand muscles are not so good for playing double bass, so I plugged in my controller, and ended up being REALLY happy with how it controls. I ended up having to play around with how all the ephemera was set up (buttons for bombs, pills, "spacebar" items, map button) a little bit, but now i'm at a place where I suck, but at least I can't complain about it being the control scheme's fault!