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It takes some real major justification and long-time work to justify that huge of a salary in your grant package. Here's a table of average salaries by field and rank. The average for a full professor in biomedical sciences - FULL - is about half that. Also NIH's paylines are shit. There's a guy named Yuntao Wu - brilliant HIV investigator, mentioned in the textbook of the HIV class I took last summer - who is basically preparing to move to China because his money went down the crapper, last I heard. (He may have changed his plans. I don't know. He's still in the United States.) Relative in NIH grants says that handwringing and complaining is de rigueur in Bethesda these days.