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What's tricky about that? It says "congress shall make no law." That means discrimination can't be written in. It's specifically written in such a way that it doesn't write it out, either; that's all handled by the fourth and tenth amendments.
The hospital in your example would have a hard time doing anything about your anti-vax guy if he didn't do it at work - and if he did it at work, their first move has to be to ask him not to do it at work. Anything he does in his private time is protected. Even stuff he does in his public time is protected - Target, for example, has a league of pharmacists who refuse to dispense birth control pills and they're constitutionally protected.
I say the anti-vax guy can do what he pleases on his own time. As long as it's legal, and he doesn't use the Hospital's name or authority to help his idiot cause.
As for the Target employees, I think they should be able to be fired. Should a Jain be able to work at McDonald's and refuse to serve anything but fries?