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Ah, if we're keeping with the physics metaphor, then the second derivative of one's life trajectory would be one's acceleration through life. It seems you are correct that rapid acceleration--or, as in the case of the author, life coming to a screeching halt--of one's life can create an enormous amount of stress. By the same token, it can be a great motivator to success. I think having a mastectomy, especially at age 31, would probably leave any woman horribly depressed.