The niche is as important as the disease. I long for the day when this or that gene pathway is inconsequential to fighting cancer. The reductionist approach is silly, but seems to be getting more entrenched, not less, with the advent of whole genome mapping, proteomics, exome sequencing, etc. Game theory seems as good a place as any to develop a new approach to cancer fighting. I personally believe many diseases (say, MS or ALS, for example), not just cancer, are systemic in nature, and they can therefore only really be understood at a systems level, as opposed to the reigning view that says that the molecular level is king. I'm not saying molecular biology isn't important; it is, as drugs act on molecules. But systems level thinking may lead to new avenues of exploration of what to target with a new drug. I.e. sometimes the causative agents we're after are not immediately obvious in a complex biological system.