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As someone who spent a lot of time with friends acclimating (or not) to the altitude, the rule of thumb we professed was seven days. We had the only olympic-sized swimming pool at 7000 feet or higher so we had athletes show up from around the world. None of them stayed for less than two weeks. When I came down to sea level for the first time, it took ten days to acclimate the other way. I had been running 8 miles a day at 7200 feet so my first week in Bellingham involved like 12-mile runs. It was nuts.