Oh, sorry for the confusion, I just meant that the FA models upregulate PSEN1 as well (right?). I was referring to the microglia activation, but you def answered my question and more. Yeah, I def want to see this paper. As much as I remember, microglia activation around AD plaques was nothing new, even without external stimulation, but the relevance here is early induction, which can be a can of worms. Wild shit, and hopefully there is some clinical relevance to it.Had no one seen that before?
Note they switch the explanation from "hippocampus" to "visual cortex" when they explain that in the video though. In theory, any signal that gets a stimulus at 40 Hz to the hippocampus should be effective, but not all circuits from the eyes / ears / mouth / fingers / nose are as direct.