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thundara · 3341 days ago · link · · parent · post: Individual neurons may carry up to 1,000 genetic mutations not present in surrounding cells
mk: You might appreciate this recent paper. They looked at a signaling pathway downstream of NMDA receptors and saw that DNA breaks were a natural part of the transcriptional activation of a number of genes associated with learning and memory. Definitely an exciting lead, though it's unclear yet what exact role these breaks and mutations have in aging and disease.