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As I near the end of my PhD, I would add the following advice. Don't undervalue your creative time or your sleep. By creative time, I mean hiking, dog walking, making a bird house, etc. Make time for our mind to wander.
My research direction became clear to me while I was daydreaming on a family vacation. Subsequent dog walks have set me up for a good five years of material. As far as advisors go, I quote Arthur C Clarke: When a distinguished but elderly scientist states that something is possible, he is almost certainly right. When he states that something is impossible, he is very probably wrong.