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In my twenties I decided to give up alcohol for a semester because I was going out more than I needed to, and I wanted to focus on productivity. As it turned out, it was no problem whatsoever. Problem was that I ended up going out to bars/clubs just as much, -I just didn't drink. My problem was that I was too social :)
For myself, giving up alcohol would be infinitely easier than giving up Coke. I love me my Coca Cola. Luckily, I have never tried smoking. It looks cool, and I bet I would like it, so I think I'll keep abstaining. I don't want to fork over a bunch of dough to give myself cancer...