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If you have to ask, choose Ubuntu. Ubuntu is far and away the most accessible to Linux newbies. The Xubuntu and Kubuntu variants are actually better, though. However, if you're wanting to move beyond Ubuntu, there are many options. Arch, Slackware and Gentoo are three common enthusiast destinations. Fedora, OpenSUSE and Debian itself are common moderately-involved choices. Zealotry aside, there is no one be-all end-all distribution, so it may be wise to try a few before settling on one. DistroWatch may also be useful.